Royal Air Force Typhoon jets have conducted a mission with French warplanes in a combined operation against an hidden munitions depot in Syria operated by the IS group, as stated by the UK's MoD.
The facility, located using surveillance, was believed to be housing weapons and explosive materials, the statement said, and was located in hills just to the north of the historic site of Palmyra in central Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to hit a several entry passages providing entry to the depot... initial indications are that the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the strike late on Saturday and each participating jet made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - established extremist governance over large swathes of Syria and Iraq prior to its 2019 collapse.
"This operation underscores our UK leadership, and resolve to stand shoulder to shoulder with our partners, to eradicate any resurgence of IS and their harmful and extremist ideologies in the area," UK Defence Secretary John Healey remarked.
UK warplanes have conducted overwatch operations over Syrian airspace to "prevent any efforts to regroup" of the group after its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I must thank the personnel of British forces who took part in this mission for their expertise and their valour," he added. "Including them were numerous British personnel on duty over Christmas and New Year. This operation, to take out dangerous terrorists who pose a risk to our safety, highlights how British military are prepared to act, throughout the year, ensuring Britain's security domestically and strong abroad."
In December, the American forces executed what it called a "massive strike" against IS targets in the country, following an ambush resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The United Nations reports Islamic State still boasts roughly 5-7 thousand combatants in Iraq and Syria.